Neurodevelopmental problems should be considered in children with febrile seizures

Nilsson, G., Westerlund, J., Fernell, E., Billstedt, E., Miniscalco, C., Arvidsson, T., Olsson, I. and Gillberg, C. (2019) Neurodevelopmental problems should be considered in children with febrile seizures. Acta Paediatrica, 108(8), pp. 1507-1514. (doi: 10.1111/apa.14716) (PMID:30614569)

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Abstract

AIM:Clinical developmental phenotyping of four- to five-year-old children with febrile seizures (FSs). METHODS:Children with FS (n = 157, corresponding to 3.7% of the targeted general population of four-five-year-olds) had been identified at child healthcare centres in Gothenburg. Parents of 73 children (41 boys, 32 girls) accepted participation in the present study. The assessments included a neuropaediatric assessment, Movement ABC, Wechsler Preschool and Primary Scale of Intelligence-III and parent questionnaires (Five-to-Fifteen (FTF) and Strengths and Difficulties Questionnaire (SDQ)). Hospital records were reviewed, when applicable. RESULTS:One-third of the children had at least one DSM-5 neurodevelopmental disorder diagnosis or marked developmental problems within areas of attention, activity regulation, behaviour, speech and language, general cognition or motor functioning. No differences were found between children with single vs recurrent or simple vs complex FS. CONCLUSION:Febrile seizure are relatively often associated with Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCEs). We found no indications that ESSENCE might be caused by FS per se. However, the results suggest that child healthcare professionals should consider the possibility of ESSENCE in children with a history of FS.

Item Type:Articles
Additional Information:Financial support was given by the Local Research and Development Council of the Vastra Gotaland Region,Margarethahem Foundation, the Linnea and Josef Carlsson Foundation, the Wilhelm and Martina Lundgren Foundation, the Queen Silvia Foundation (G.N.), Per and Ann-marie Ahlqvist Foundation (C.G.).
Status:Published
Refereed:No
Glasgow Author(s) Enlighten ID:Gillberg, Professor Christopher
Authors: Nilsson, G., Westerlund, J., Fernell, E., Billstedt, E., Miniscalco, C., Arvidsson, T., Olsson, I., and Gillberg, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Acta Paediatrica
Publisher:Wiley
ISSN:0803-5253
ISSN (Online):1651-2227
Published Online:06 February 2019

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