Abnormal Cortical Network Activation in Human Amnesia: A High-resolution Evoked Potential Study

Barcellona-Lehmann, S., Morand, S. , Bindschaedler, C., Nahum, L., Gabriel, D. and Schnider, A. (2010) Abnormal Cortical Network Activation in Human Amnesia: A High-resolution Evoked Potential Study. Brain Topography, 23(1), pp. 72-81. (doi:10.1007/s10548-009-0124-3) (PMID:19960364)

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Abstract

Little is known about how human amnesia affects the activation of cortical networks during memory processing. In this study, we recorded high-density evoked potentials in 12 healthy control subjects and 11 amnesic patients with various types of brain damage affecting the medial temporal lobes, diencephalic structures, or both. Subjects performed a continuous recognition task composed of meaningful designs. Using whole-scalp spatiotemporal mapping techniques, we found that, during the first 200 ms following picture presentation, map configuration of amnesics and controls were indistinguishable. Beyond this period, processing significantly differed. Between 200 and 350 ms, amnesic patients expressed different topographical maps than controls in response to new and repeated pictures. From 350 to 550 ms, healthy subjects showed modulation of the same maps in response to new and repeated items. In amnesics, by contrast, presentation of repeated items induced different maps, indicating distinct cortical processing of new and old information. The study indicates that cortical mechanisms underlying memory formation and re-activation in amnesia fundamentally differ from normal memory processing.

Item Type:Articles
Additional Information:The study was supported by Swiss National Science Foundation grant no. 320000-113436 to A.S.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morand, Dr Stephanie
Authors: Barcellona-Lehmann, S., Morand, S., Bindschaedler, C., Nahum, L., Gabriel, D., and Schnider, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Brain Topography
Publisher:Springer
ISSN:0896-0267
ISSN (Online):1573-6792
Published Online:04 December 2009

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