Improvement of parenteral nutrition-associated cholestasis in an adult using fish oil-based parenteral nutrition

Moyes, L.H., Hamid, R., Clutton, J., Oien, K.A. , McKee, R.F. and Forrest, E.H. (2012) Improvement of parenteral nutrition-associated cholestasis in an adult using fish oil-based parenteral nutrition. Frontline Gastroenterology, 3(2), pp. 94-97. (doi: 10.1136/flgastro-2011-100056) (PMID:28839644) (PMCID:PMC5517263)

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Abstract

Parenteral nutrition-associated cholestasis (PNAC) is a severe complication of parenteral nutrition. Standard feed preparations contain soybean and olive oil that are rich in ω-6 polyunsaturated fats, and which studies suggest can be hepatotoxic. Preparations containing fish oil, rich in ω-3 polyunsaturated fats, may be hepatoprotective and have been used in the critical care setting as immunotherapy. A case demonstrating dramatic improvement in liver function and overall clinical condition in an adult with PNAC and intestinal failure within 8 weeks of changing to a fish oil-based parenteral feed is reported. As far as is known, this is the first report of an adult patient whose parenteral nutrition-associated liver disease resolved after a parenteral nutrition lipid emulsion was changed to the fish oil-containing emulsion, SMOFlipid.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McKee, Dr Ruth and Oien, Professor Karin and Moyes, Dr Lisa and Forrest, Dr Ewan
Authors: Moyes, L.H., Hamid, R., Clutton, J., Oien, K.A., McKee, R.F., and Forrest, E.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Frontline Gastroenterology
Publisher:BMJ Publishing Group
ISSN:2041-4137
ISSN (Online):2041-4145
Published Online:13 March 2012

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