Changes in cardiopulmonary reserve and peripheral arterial function concomitantly with subclinical inflammation and oxidative stress in patients with heart failure with preserved ejection fraction

Vitiello, D. et al. (2014) Changes in cardiopulmonary reserve and peripheral arterial function concomitantly with subclinical inflammation and oxidative stress in patients with heart failure with preserved ejection fraction. International Journal of Vascular Medicine, 2014, 917271. (doi: 10.1155/2014/917271) (PMID:24719767) (PMCID:PMC3955597)

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Abstract

Background. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL). Methods and Results. Eighteen HFpEF patients and 14 CTL were recruited. Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest. Brain natriuretic peptide (BNP) was measured at rest and peak exercise. Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses. Peripheral arterial blood flow was determined by strain gauge plethysmography. Peak VO2 ( versus  mL/min/kg, ) and oxygen uptake efficiency slope ( versus , ) were significantly decreased in HFpEF patients compared with CTL. BNP at rest and following stress, C-reactive-protein, interleukin-6, and TBARS were significantly elevated in HFpEF. Both basal and posthyperemic arterial blood flow were not significantly different between the HFpEF patients and CTL. Conclusions. HFpEF exhibits a severe reduction in cardiopulmonary reserve and oxygen uptake efficiency concomitantly with an elevation in a broad spectrum of biomarkers confirming an inflammatory and prooxidative status in patients with HFpEF.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Touyz, Professor Rhian
Authors: Vitiello, D., Harel, F., Touyz, R. M., Sirois, M. G., Lavoie, J., Myers, J., Ducharme, A., Racine, N., O’Meara, E., Gayda, M., Chabot-Blanchet, M., Rouleau, J. L., de Denus, S., and White, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Vascular Medicine
Publisher:Hindawi
ISSN:2090-2824
ISSN (Online):2090-2832
Copyright Holders:Copyright © 2014 Damien Vitiello et al.
First Published:First published in International Journal of Vascular Medicine 2014:917271
Publisher Policy:Reproduced under a Creative Commons license

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