MicroRNAs in AKI and kidney transplantation

Ledeganck, K. J., Gielis, E. M., Abramowicz, D., Stenvinkel, P., Shiels, P. G. and Van Craenenbroeck, A. H. (2019) MicroRNAs in AKI and kidney transplantation. Clinical Journal of the American Society of Nephrology, 14(3), pp. 454-468. (doi: 10.2215/CJN.08020718)

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Abstract

MicroRNAs are epigenetic regulators of gene expression at the posttranscriptional level. They are involved in intercellular communication and crosstalk between different organs. As key regulators of homeostasis, their dysregulation underlies several morbidities including kidney disease. Moreover, their remarkable stability in plasma and urine makes them attractive biomarkers. Beyond biomarker studies, clinical microRNA research in nephrology in recent decades has focused on the discovery of specific microRNA signatures and the identification of novel targets for therapy and/or disease prevention. However, much of this research has produced equivocal results and there is a need for standardization and confirmation in prospective trials. This review aims to provide an overview of general concepts and available clinical evidence in both the pathophysiology and biomarker fields for the role of microRNA in AKI and kidney transplantation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Ledeganck, K. J., Gielis, E. M., Abramowicz, D., Stenvinkel, P., Shiels, P. G., and Van Craenenbroeck, A. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Clinical Journal of the American Society of Nephrology
Publisher:American Society of Nephrology
ISSN:1555-9041
ISSN (Online):1555-905X
Published Online:08 March 2019
Copyright Holders:Copyright © 2019 American Society of Nephrology
First Published:First published in Clinical Journal of the American Society of Nephrology 14(3):454-468
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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