Mas signaling: resolved and unresolved issues

Montezano, A. C., Nguyen Dinh Cat, A. and Touyz, R. M. (2015) Mas signaling: resolved and unresolved issues. In: Unger, T., Steckelings, U. M. and dos Santos, R. A.S. (eds.) The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Academic Press, pp. 169-179. ISBN 9780128013649 (doi:10.1016/B978-0-12-801364-9.00023-7)

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Abstract

The Mas oncogene encodes for a seven-transmembrane G protein-coupled receptor (GPCR), Mas, which has a ubiquitous distribution. Mas is abundantly expressed in the brain and testes but is also found in the heart, kidneys, lungs, vasculature, adipose tissue, and skeletal muscle. Ang-(1-7) is the endogenous ligand that binds to Mas. Ang-(1-7)/Mas constitutes part of the protective axis of the renin– angiotensin system. Mas signals through many pathways including NOS, PI3K/Akt, MAP kinases, RhoA, and cAMP/PKA. Mas also regulates protein tyrosine phosphatases, such as SHP-1 and SHP-2. Mas may form functional heterodimers with other GPCRs, such as AT1R and bradykinin receptors, and as such, Ang-(1-7) may negatively regulate Ang II through interactions between cognate receptors. Activation of Mas by Ang-(1-7) causes vasodilation, anti-inflammatory and antifibrotic effects, natriuresis and diuresis, and improved lipid and glucose metabolism through increased insulin sensitivity. Because of these beneficial actions of Mas activation, there is growing interest in developing Mas agonists, which may have therapeutic potential. In addition to binding Ang-(1-7), Mas may bind other, as yet undefined, ligands. The physiological significance of this however remains unclear. Here, we provide an overview of the Mas receptor focusing on the known pathways through which Ang-(1-7)/Mas signals. We also discuss the many unknowns relating to Mas signaling.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Nguyen Dinh Cat, Dr Aurelie and Montezano, Dr Augusto and Touyz, Professor Rhian
Authors: Montezano, A. C., Nguyen Dinh Cat, A., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Publisher:Academic Press
ISBN:9780128013649

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