The role of sphingosine-1-phosphate in smooth muscle contraction

Watterson, K. R., Ratz, P. H. and Spiegel, S. (2005) The role of sphingosine-1-phosphate in smooth muscle contraction. Cellular Signalling, 17(3), pp. 289-298. (doi:10.1016/j.cellsig.2004.09.013) (PMID:15567060)

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Abstract

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that is known to mediate diverse cellular responses including cell growth, survival, and migration. Most of these effects have been attributed to its binding to a specific subfamily of G protein-coupled receptors (GPCR), namely S1P(1-5). Recent studies have suggested that S1P also plays a prominent role in the contraction of various types of smooth muscle. This review provides a brief overview of its role in this process and also highlights how S1P-dependent signaling serves as an important regulator of smooth muscle contraction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Watterson, Dr Kenneth
Authors: Watterson, K. R., Ratz, P. H., and Spiegel, S.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Cellular Signalling
Publisher:Elsevier
ISSN:0898-6568
ISSN (Online):1873-3913
Published Online:20 October 2004

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