Watterson, K. R., Ratz, P. H. and Spiegel, S. (2005) The role of sphingosine-1-phosphate in smooth muscle contraction. Cellular Signalling, 17(3), pp. 289-298. (doi: 10.1016/j.cellsig.2004.09.013) (PMID:15567060)
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Abstract
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that is known to mediate diverse cellular responses including cell growth, survival, and migration. Most of these effects have been attributed to its binding to a specific subfamily of G protein-coupled receptors (GPCR), namely S1P(1-5). Recent studies have suggested that S1P also plays a prominent role in the contraction of various types of smooth muscle. This review provides a brief overview of its role in this process and also highlights how S1P-dependent signaling serves as an important regulator of smooth muscle contraction.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Watterson, Dr Kenneth |
| Authors: | Watterson, K. R., Ratz, P. H., and Spiegel, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Cellular Signalling |
| Publisher: | Elsevier |
| ISSN: | 0898-6568 |
| ISSN (Online): | 1873-3913 |
| Published Online: | 20 October 2004 |
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