Setting our sights on infectious diseases

De Rycker, M. et al. (2020) Setting our sights on infectious diseases. ACS Infectious Diseases, 6(1), pp. 3-13. (doi: 10.1021/acsinfecdis.9b00371) (PMID:31808676) (PMCID:PMC6958537)

Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cook, Professor Sarah
• Authors: De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V., Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W., White, N. J., Wyllie, S., Wyatt, P. G., and Gilbert, I. H.
• College/School: College of Arts & Humanities > School of Humanities > Information Studies
• Journal Name: ACS Infectious Diseases
• Publisher: American Chemical Society
• ISSN: 2373-8227
• ISSN (Online): 2373-8227
• Published Online: 06 December 2019
• Copyright Holders: Copyright © 2019 American Chemical Society
• First Published: First published in ACS Infectious Diseases 6(1): 3-13
• Publisher Policy: Reproduced under a Creative Commons License