The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Annese, V. F. et al. (2019) The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform. In: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), Otranto, Italy, 13-14 Jun 2019, pp. 130-135. ISBN 9781728105574 (doi:10.1109/IWASI.2019.8791347)

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Abstract

The use of CMOS platforms in medical point-of-care applications, by integrating all steps from sample to data output, has the potential to reduce the diagnostic cost and the time from days to seconds. Here we present the `Multicorder' technology, a handheld versatile multimodal platform for rapid metabolites quantification. The current platform is composed of a cartridge, a reader and a graphic user interface. The sensing core of the cartridge is the CMOS chip which integrates a 16×16 array of multi-sensor elements. Each element is composed of two optical and one chemical sensor. The platform is therefore capable of performing multi-mode measurements: namely colorimetric, chemiluminescence, pH sensing and surface plasmon resonance. In addition to the reader that is employed for addressing, data digitization and transmission, a tablet computer performs data collection, visualization, analysis and storage. In this paper, we demonstrate colorimetric, chemiluminescence and pH sensing on the same platform by on-chip quantification of different metabolites in their physiological range. The platform we have developed has the potential to lead the way to a new generation of commercial devices in the footsteps of the current commercial glucometers for quick multi-metabolite quantification for both acute and chronic medicines.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Velugotla, Dr Srinivas and Grant, Dr James and Cumming, Professor David and Hu, Dr Chunxiao and Accarino, Mr Claudio and Giagkoulovits, Mr Christos and Annese, Valerio and Beeley, Dr James and Patil, Dr Samadhan and Cheah, Dr Boon Chong
Authors: Annese, V. F., Hu, C., Accarino, C., Giagkoulovits, C., Patil, S. B., Al-Rawhani, M. A., Beeley, J., Cheah, B. C., Velugotla, S., Grant, J. P., and Cumming, D. R.S.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
ISBN:9781728105574
Copyright Holders:Copyright © 2019 IEEE
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190623The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - Electronics & Nanoscale Engineering
190796Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/L023652/1Chemistry