Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Subbiah, M. et al. (2020) Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania. Nature Communications, 11, 228. (doi: 10.1038/s41467-019-13995-5) (PMID:31932601) (PMCID:PMC6957491)

[img]
Preview
Text
205390.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mair, Dr Colette and Matthews, Professor Louise
Authors: Subbiah, M., Caudell, M. A., Mair, C., Davis, M. A., Matthews, L., Quinlan, R. J., Quinlan, M. B., Lyimo, B., Buza, J., Keyyu, J., and Call, D. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723
ISSN (Online):2041-1723
Published Online:13 January 2020
Copyright Holders:Copyright © The Authors 2020
First Published:First published in Nature Communications 11:228
Publisher Policy:Reproduced under a Creative Commons license

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190643Ecological and socioeconomic factors impacting maintenance and dissemination of antibiotic resistance in the Greater Serengeti EcosystemLouise MatthewsBiotechnology and Biological Sciences Research Council (BBSRC)BB/K01126X/1Institute of Biodiversity, Animal Health and Comparative Medicine