The BRCA2 transactivation domain does not interact with JNK

May, G. H.W. , Harris, F., Gillespie, D. and Black, D.M. (1999) The BRCA2 transactivation domain does not interact with JNK. Genes, Chromosomes and Cancer, 25(4), pp. 407-9. (doi: 10.1002/(SICI)1098-2264(199908)25:4<407::AID-GCC16>3.0.CO;2-I) (PMID:10398438)

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The N-terminal region of BRCA2 has the capacity to activate transcription when fused to a heterologous DNA binding domain and includes a segment with amino acid similarity to the JNK-docking site in the cellular JUN protein. However, unlike JUN, we have determined that this region of BRCA2 neither interacts with nor serves as a substrate for JNK, or any other kinase that can be detected in extracts from either fibroblasts or epithelial cells. While this clearly does not rule out a transcriptional role for BRCA2, our findings indicate that BRCA2 is not regulated by the JNK pathway in a manner analogous to JUN.

Item Type:Articles (Letter)
Glasgow Author(s) Enlighten ID:May, Dr Gerhard
Authors: May, G. H.W., Harris, F., Gillespie, D., and Black, D.M.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Genes, Chromosomes and Cancer
ISSN (Online):1098-2264
Published Online:07 July 1999

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