May, G. H.W. , Harris, F., Gillespie, D. and Black, D.M. (1999) The BRCA2 transactivation domain does not interact with JNK. Genes, Chromosomes and Cancer, 25(4), pp. 407-9. (doi: 10.1002/(SICI)1098-2264(199908)25:4<407::AID-GCC16>3.0.CO;2-I) (PMID:10398438)
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Abstract
The N-terminal region of BRCA2 has the capacity to activate transcription when fused to a heterologous DNA binding domain and includes a segment with amino acid similarity to the JNK-docking site in the cellular JUN protein. However, unlike JUN, we have determined that this region of BRCA2 neither interacts with nor serves as a substrate for JNK, or any other kinase that can be detected in extracts from either fibroblasts or epithelial cells. While this clearly does not rule out a transcriptional role for BRCA2, our findings indicate that BRCA2 is not regulated by the JNK pathway in a manner analogous to JUN.
| Item Type: | Articles (Letter) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | May, Dr Gerhard |
| Authors: | May, G. H.W., Harris, F., Gillespie, D., and Black, D.M. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry Q Science > QH Natural history > QH426 Genetics |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Genes, Chromosomes and Cancer |
| Publisher: | Wiley |
| ISSN: | 1045-2257 |
| ISSN (Online): | 1098-2264 |
| Published Online: | 07 July 1999 |
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