Sutherland, T. E., Logan, N., Rückerl, D., Humbles, A. A., Allan, S. M., Papayannopoulos, V., Stockinger, B., Maizels, R. M. and Allen, J. E. (2014) Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage. Nature Immunology, 15(12), pp. 1116-1125. (doi: 10.1038/ni.3023) (PMID:25326751) (PMCID:PMC4338525)
Full text not currently available from Enlighten.
Abstract
Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We found that Ym1 and Ym2 induced the accumulation of neutrophils through the expansion of γδ T cell populations that produced interleukin 17 (IL-17). While BRP-39 did not influence neutrophilia, it was required for IL-17 production in γδ T cells, which suggested that regulation of IL-17 is an inherent feature of mouse CLPs. Analysis of a nematode infection model, in which the parasite migrates through the lungs, revealed that the IL-17 and neutrophilic inflammation induced by Ym1 limited parasite survival but at the cost of enhanced lung injury. Our studies describe effector functions of CLPs consistent with innate host defense traits of the chitinase family.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
| Authors: | Sutherland, T. E., Logan, N., Rückerl, D., Humbles, A. A., Allan, S. M., Papayannopoulos, V., Stockinger, B., Maizels, R. M., and Allen, J. E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Immunology |
| Publisher: | Nature Research |
| ISSN: | 1529-2908 |
| ISSN (Online): | 1529-2916 |
| Published Online: | 19 October 2014 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details