McSorley, H.J., Blair, N.F., Smith, K.A., McKenzie, A.N.J. and Maizels, R.M. (2014) Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology, 7(5), pp. 1068-1078. (doi: 10.1038/mi.2013.123) (PMID:24496315) (PMCID:PMC4016792)
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Abstract
Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H. polygyrus (HES) potently suppress inflammation induced by allergens from the common fungus Alternaria alternata. Alternaria extract, when administered to mice intranasally with ovalbumin (OVA) protein, induces a rapid (1–48 h) innate response while also priming an OVA-specific Th2 response that can be evoked 14 days later by intranasal administration of OVA alone. In this model, HES coadministration with Alternaria/OVA suppressed early IL-33 release, innate lymphoid cell (ILC) production of IL-4, IL-5, and IL-13, and localized eosinophilia. Upon OVA challenge, type 2 ILC (ILC2)/Th2 cytokine production and eosinophilia were diminished in HES-treated mice. HES administration 6 h before Alternaria blocked the allergic response, and its suppressive activity was abolished by heat treatment. Administration of recombinant IL-33 at sensitization with Alternaria/OVA/HES abrogated HES suppression of OVA-specific responses at challenge, indicating that suppression of early Alternaria-induced IL-33 release could be central to the anti-allergic effects of HES. Thus, this helminth parasite targets IL-33 production as part of its armory of suppressive effects, forestalling the development of the type 2 immune response to infection and allergic sensitization.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
Authors: | McSorley, H.J., Blair, N.F., Smith, K.A., McKenzie, A.N.J., and Maizels, R.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Mucosal Immunology |
Publisher: | Springer Nature |
ISSN: | 1933-0219 |
ISSN (Online): | 1935-3456 |
Published Online: | 05 February 2014 |
Copyright Holders: | Copyright © 2014 Society for Mucosal Immunology |
First Published: | First published in Mucosal Immunology 7(5):1068-1078 |
Publisher Policy: | Reproduced under a Creative Commons license |
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