Johnston, C. J.C., McSorley, H. J., Anderton, S. M., Wigmore, S. J. and Maizels, R. M. (2014) Helminths and immunological tolerance. Transplantation, 97(2), pp. 127-132. (doi: 10.1097/TP.0b013e3182a53f59) (PMID:24025322) (PMCID:PMC3940291)
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Abstract
Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection. Achievement of immunological tolerance (long-term antigen unresponsiveness in an immunocompetent host) presents the exciting prospect of freedom from immunosuppression for transplant recipients. It is now 60 years since the first demonstration of immunological tolerance in animal models of transplantation, but translation into routine clinical practice remains elusive. Helminth parasites may provide novel strategies toward achieving this goal. Helminths are remarkably successful parasites: they currently infect more than one quarter of the world’s population. It is now well established that the parasites’ success is the result of active immunomodulation of their hosts’ immune response. Although this primarily secures ongoing survival of the parasites, helminth-induced immunomodulation can also have a number of benefits for the host. Significant reductions in the prevalence of allergy and autoimmune conditions among helminth-infected populations are well recognized and there is now a significant body of evidence to suggest that harmful immune responses to alloantigens may be abrogated as well. Here, we review all existing studies of helminth infection and transplantation, explore the mechanisms involved, and discuss possible avenues for future translation to clinical practice.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
| Authors: | Johnston, C. J.C., McSorley, H. J., Anderton, S. M., Wigmore, S. J., and Maizels, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Transplantation |
| Publisher: | Lippincott, Williams and Wilkins |
| ISSN: | 0041-1337 |
| ISSN (Online): | 1534-6080 |
| Copyright Holders: | Copyright © 2013 by Lippincott Williams and Wilkins |
| First Published: | First published in Transplantation Journal 97(2):127-132 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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