Aldosterone blockade in post-acute myocardial infarction heart failure

Pitt, B., Ferrari, R., Gheorghiade, M., van Veldhuisen, D.J., Krum, H., McMurray, J. and Lopez-Sendon, J. (2006) Aldosterone blockade in post-acute myocardial infarction heart failure. Clinical Cardiology, 29(10), pp. 434-438. (doi:10.1002/clc.4960291004) (PMID:17063946)

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Abstract

Development of heart failure (HF) or left ventricular systolic dysfunction (LVSD) significantly increases mortality post acute myocardial infarction (AMI). Aldosterone contributes to the development and progression of HF post AMI, and major guidelines now recommend aldosterone blockade in this setting. However, lack of practical experience with aldosterone blockade may make clinicians hesitant to use these therapies. This review is based on a consensus cardiology conference that occurred in May 2005 (New York City) concerning these topics. Potential barriers to the use of aldosterone blockade are discussed and an algorithm for appropriate in-hospital pharmacologic management of AMI with LVSD and/or HF is presented.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: Pitt, B., Ferrari, R., Gheorghiade, M., van Veldhuisen, D.J., Krum, H., McMurray, J., and Lopez-Sendon, J.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Clinical Cardiology
Publisher:Wiley
ISSN:0160-9289
ISSN (Online):1932-8737

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