After TOPCAT: what to do now in heart failure with preserved ejection fraction

Desai, A. S. and Jhund, P. S. (2016) After TOPCAT: what to do now in heart failure with preserved ejection fraction. European Heart Journal, 37(41), pp. 3135-3140. (doi: 10.1093/eurheartj/ehw114) (PMID:27075872)

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Abstract

Although patients with heart failure and preserved ejection fraction (HF-PEF) represent nearly half of the population with chronic heart failure, few evidence-based medical therapies are available. The neutral overall results of the TOPCAT trial of spironolactone in HF-PEF leave clinicians who treat heart failure with an ongoing clinical dilemma. In this review, we outline an approach to the clinical management of the patient with HF-PEF synthesizing data from available clinical trials and expert consensus.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jhund, Dr Pardeep
Authors: Desai, A. S., and Jhund, P. S.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:European Heart Journal
Publisher:Oxford University Press
ISSN:0195-668X
ISSN (Online):1522-9645
Published Online:13 April 2016

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