Temporal modulation of the response of sensory fibers to paired-pulse stimulation

Brunton, E. K., Silveira, C., Rosenberg, J., Schiefer, M. A., Riddell, J. and Nazarpour, K. (2019) Temporal modulation of the response of sensory fibers to paired-pulse stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 27(9), pp. 1676-1683. (doi: 10.1109/TNSRE.2019.2935813) (PMID:31425119)

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Abstract

Multi-channel nerve cuff electrode arrays can provide sensory feedback to prosthesis users. To develop efficacious stimulation protocols, an understanding of the impact that spatio-temporal patterned stimulation can have on the response of sensory fibers is crucial. We used experimental and modelling methods to investigate the response of nerve fibers to paired-pulse stimulation. Nerve cuff electrode arrays were implanted for stimulation of the sciatic nerves of rats and the sensory compound action potentials were recorded from the L4 dorsal root. A model of the nerve cuff electrode array and sciatic nerve was also developed. The experimental and modelling results were compared. Experiments showed that it took 8 ms for the sensory fibers to completely recover from a conditioning stimulus, regardless of the relative position of the electrodes used for stimulation. The results demonstrate that the electrodes on the cuff cannot be considered independent. Additionally, at 120% of the threshold, there is a large overlap in the fibers that were activated by the different electrodes. If a stimulus paradigm considered the electrodes as independent, stimuli from the different electrodes would need to be interleaved, and the intervals between the stimuli should be greater than 8 ms.

Item Type:Articles
Additional Information:This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) Research Grants EP/M025977/1, EP/N023080/1, and EP/R004242/1.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Riddell, Professor John
Authors: Brunton, E. K., Silveira, C., Rosenberg, J., Schiefer, M. A., Riddell, J., and Nazarpour, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:IEEE Transactions on Neural Systems and Rehabilitation Engineering
Publisher:IEEE
ISSN:1534-4320
ISSN (Online):1558-0210
Published Online:19 August 2019
Copyright Holders:Copyright © 2019 IEEE
First Published:First published in IEEE Transactions on Neural Systems and Rehabilitation Engineering 27(9): 1676-1683
Publisher Policy:Reproduced in accordance with the publisher copyright policy
Data DOI:10.17634/154300-105

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