Brunton, E. K., Silveira, C., Rosenberg, J., Schiefer, M. A., Riddell, J. and Nazarpour, K. (2019) Temporal modulation of the response of sensory fibers to paired-pulse stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 27(9), pp. 1676-1683. (doi: 10.1109/TNSRE.2019.2935813) (PMID:31425119)
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203625.pdf - Accepted Version 659kB |
Abstract
Multi-channel nerve cuff electrode arrays can provide sensory feedback to prosthesis users. To develop efficacious stimulation protocols, an understanding of the impact that spatio-temporal patterned stimulation can have on the response of sensory fibers is crucial. We used experimental and modelling methods to investigate the response of nerve fibers to paired-pulse stimulation. Nerve cuff electrode arrays were implanted for stimulation of the sciatic nerves of rats and the sensory compound action potentials were recorded from the L4 dorsal root. A model of the nerve cuff electrode array and sciatic nerve was also developed. The experimental and modelling results were compared. Experiments showed that it took 8 ms for the sensory fibers to completely recover from a conditioning stimulus, regardless of the relative position of the electrodes used for stimulation. The results demonstrate that the electrodes on the cuff cannot be considered independent. Additionally, at 120% of the threshold, there is a large overlap in the fibers that were activated by the different electrodes. If a stimulus paradigm considered the electrodes as independent, stimuli from the different electrodes would need to be interleaved, and the intervals between the stimuli should be greater than 8 ms.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) Research Grants EP/M025977/1, EP/N023080/1, and EP/R004242/1. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Riddell, Professor John |
| Authors: | Brunton, E. K., Silveira, C., Rosenberg, J., Schiefer, M. A., Riddell, J., and Nazarpour, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| Publisher: | IEEE |
| ISSN: | 1534-4320 |
| ISSN (Online): | 1558-0210 |
| Published Online: | 19 August 2019 |
| Copyright Holders: | Copyright © 2019 IEEE |
| First Published: | First published in IEEE Transactions on Neural Systems and Rehabilitation Engineering 27(9): 1676-1683 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
| Data DOI: | 10.17634/154300-105 |
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