RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Brady, M. C. et al. (2020) RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. Aphasiology, 34(2), pp. 137-157. (doi: 10.1080/02687038.2019.1643003)

Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)

• Item Type: Articles
• Additional Information: This project was funded by the National Institute for Health Research (NIHR), Health Services and Delivery Research Programme [HS&DR–14/04/22] and will be published in full in the Health Services and Delivery Research Journal. Further information available at https://www.aphasia trials.org/RELEASE. MCB is funded by the Chief Scientist Office (CSO), Scottish Government Health and Social Care Directorates. This article is based upon work from Collaboration of Aphasia Trialists supported by COST (European Cooperation in Science and Technology [IS1208 2013-2017]) and the Tavistock Trust for Aphasia (TTA) (2017–2020). This report presents independent research commissioned by the National Institute for Health Research (NIHR).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ali, Dr Myzoon and Hawkins, Professor Neil
• Authors: Brady, M. C., Ali, M., VandenBerg, K., Williams, L. J., Williams, L. R., Abo, M., Becker, F., Bowen, A., Brandenburg, C., Breitenstein, C., Bruehl, S., Copland, D. A., Cranfill, T. B., Pietro-Bachmann, M. d., Enderby, P., Fillingham, J., Galli, F. L., Gandolfi, M., Glize, B., Godecke, E., Hawkins, N., Hilari, K., Hinckley, J., Horton, S., Howard, D., Jaecks, P., Jefferies, E., Jesus, L. M. T., Kambanaros, M., Kang, E. K., Khedr, E. M., Pak-Hin Kong, A., Kukkonen, T., Laganaro, M., Lambon Ralph, M. A., Laska, A. C., Leemann, B., Leff, A. P., Lima, R. R., Lorenz, A., MacWhinney, B., Marshall, R. S., Mattioli, F., Maviş, İ., Meinzer, M., Nilipour, R., Noé, E., Paik, N.-J., Palmer, R., Papathanasiou, I., Patricio, B. F., Pavão Martins, I., Price, C., Jakovac, T. P., Rochon, E., Rose, M. L., Rosso, C., Rubi-Fessen, I., Ruiter, M. B., Snell, C., Stahl, B., Szaflarski, J. P., Thomas, S. A., van de Sandt-Koend, M., van der Meulen, I., Visch-Brink, E., Worrall, L., and Harris Wright, H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
• Journal Name: Aphasiology
• Publisher: Taylor & Francis
• ISSN: 0268-7038
• ISSN (Online): 1464-5041
• Published Online: 25 August 2019
• Copyright Holders: Copyright © 2019 The Author(s)
• First Published: First published in Aphasiology 34(2):137-157
• Publisher Policy: Reproduced under a Creative Commons License

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