Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: Standardization and consistency across centers

Boyle, D. et al. (2007) Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: Standardization and consistency across centers. Journal of Rheumatology, 34, pp. 620-622. (PMID:17343309)

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Publisher's URL: http://www.jrheum.org/content/34/3/620.abstract

Abstract

Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: Boyle, D., Bresnihan, B., Fitzgerald, O., Gerlag, D., Kirkham, B., McInnes, I., Rooney, T., Smeets, T., Smith, M., Tak, P., Ulfgren, A., Veale, D., and Wijbrandts, C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Rheumatology
Publisher:Journal of Rheumatology
ISSN:0315-162X
ISSN (Online):1499-2752

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