SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380

Pimlott, S. L., Piggott, M., Patterson, J., Cavanagh, J. and Wyper, D. J. (2007) SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380. Journal of Labelled Compounds and Radiopharmaceuticals, 50(5-6), pp. 350-353. (doi: 10.1002/jlcr.1192)

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Abstract

In order to image nAChR density in vivo in humans, [5-<sup>123</sup>I]-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([5-<sup>123</sup>I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, <i>in vitro</i> validation in human post-mortem tissue and some initial <i>in vivo</i> clinical studies using the ligand [5-<sup>123/125</sup>I]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patterson, Dr James and Wyper, Professor David and Pimlott, Dr Sally and Cavanagh, Professor Jonathan
Authors: Pimlott, S. L., Piggott, M., Patterson, J., Cavanagh, J., and Wyper, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Journal of Labelled Compounds and Radiopharmaceuticals
Publisher:John Wiley & Sons, Ltd.
ISSN:0362-4803
ISSN (Online):1099-1344
Published Online:30 July 2007

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