The impact of metabolic reprogramming on dendritic cell function

de Lima Thomaz, L., Peron, G., Oliveira, J., da Rosa, L. C. , Thomé, R. and Verinaud, L. (2018) The impact of metabolic reprogramming on dendritic cell function. International Immunopharmacology, 63, pp. 84-93. (doi: 10.1016/j.intimp.2018.07.031) (PMID:30075432)

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Abstract

Dendritic cells (DCs) are antigen-presenting cells with the ability to activate naïve T cells and direct the adaptive cellular immune response toward a specific profile. This is important, as different pathogens demand specific “profiles” of immune responses for their elimination. Such a goal is achieved depending on the maturation/activation status of DCs by the time of antigen presentation to T cells. Notwithstanding this, recent studies have shown that DCs alter their metabolic program to accommodate the functional changes in gene expression and protein synthesis that follow antigen recognition. In this review, we aim to summarize the data in the literature regarding the metabolic pathways involved with DC phenotypes and their functions.

Item Type:Articles
Additional Information:This work was supported by the São Paulo Research Foundation (grant number 2014/19492-3) and the Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Pesquisa, grant number 140867/2016-3).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Camargo da Rosa, Dr Larissa
Authors: de Lima Thomaz, L., Peron, G., Oliveira, J., da Rosa, L. C., Thomé, R., and Verinaud, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Immunopharmacology
Publisher:Elsevier
ISSN:1567-5769
ISSN (Online):1878-1705
Published Online:01 August 2018

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