Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS

Zorzella-Pezavento, S. F. G., Chiuso-Minicucci, F., França, T. G. D., Ishikawa, L. L. W., da Rosa, L. C. , Colavite, P. M., Marques, C., Ikoma, M. R. V., Silva, C. L. and Sartori, A. (2014) Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS. Journal of Neuroimmunology, 268(1-2), pp. 35-42. (doi: 10.1016/j.jneuroim.2013.12.015) (PMID:24439542)

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Abstract

Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Camargo da Rosa, Dr Larissa
Authors: Zorzella-Pezavento, S. F. G., Chiuso-Minicucci, F., França, T. G. D., Ishikawa, L. L. W., da Rosa, L. C., Colavite, P. M., Marques, C., Ikoma, M. R. V., Silva, C. L., and Sartori, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neuroimmunology
Publisher:Elsevier
ISSN:0165-5728
ISSN (Online):1872-8421
Published Online:06 January 2014

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