Effects of glaucoma and snoring on cerebral oxygenation in the visual cortex: a study using functional Near Infrared Spectroscopy (fNIRS)

Ward, L. M. , Aitchison, R. T., Hill, G., Imrie, J., Simmers, A., Morison, G., Mansfield, D., Kennedy, G. J. and Shahani, U. (2018) Effects of glaucoma and snoring on cerebral oxygenation in the visual cortex: a study using functional Near Infrared Spectroscopy (fNIRS). International Journal of Ophthalmology and Vision Research, 2(2), 017-025.

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Abstract

Purpose: The purpose of this study was to investigate the effects of snoring and glaucoma on the visual Haemodynamic Response (HDR) using functional Near Infrared Spectroscopy (fNIRS). Methods: We recruited 8 glaucoma patients (aged 56-79), 6 habitual snorers (aged 26-61) and 10 healthy control participants (aged 21-78). Glaucoma patients were of varying subtypes and under care of ophthalmologists. Prior to testing visual acuity, blood pressure, heart rate and a medical history were taken. HDRs were recorded over the primary visual cortex (V1) using a reversing checkerboard paradigm. Results & Discussion: All participants showed the characteristic increase of Oxyhaemoglobin concentration ([HbO]) and decrease of Deoxyhaemoglobin concentration ([HbR]) during visual stimulation (p < 0.001, η2 = 0.78). Despite this, there were signifi cant group differences with a large effect size (η2 = 0.28). During visual stimulation normal participants had greater [HbO] compared to snorers and glaucoma patients (p < 0.01). Both glaucoma patients and snorers presented with comparable HDR for [HbO] and [HbR] in V1. Importantly, during visual stimulation, the increased [HbO] in glaucoma patients correlated well with their visual fi elds and self-reported activities of daily living (r = -0.98, r = -0.82, p < 0.05). Both glaucoma patients and snorers presented with an attenuated HDR in V1. Our results suggest a possible vascular link between these conditions.

Item Type:Articles
Keywords:Glaucoma, fNIRS, haemodynamic response, oxyhaemoglobin, deoxyhaemoglobin, snorers, visual cortex.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ward, Dr Laura
Authors: Ward, L. M., Aitchison, R. T., Hill, G., Imrie, J., Simmers, A., Morison, G., Mansfield, D., Kennedy, G. J., and Shahani, U.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
Journal Name:International Journal of Ophthalmology and Vision Research
Journal Abbr.:IJOVR
Publisher:SciRes Literature
ISSN:2640-5660
Copyright Holders:Copyright © 2018 Ward LM, et al.
First Published:First published in International Journal of Ophthalmology and Vision Research 2(2): 017-025
Publisher Policy:Reproduced under a Creative Commons License

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