Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

Cao, T. H. et al. (2020) Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets. European Journal of Heart Failure, 22(1), pp. 70-80. (doi: 10.1002/ejhf.1608) (PMID:31692186) (PMCID:PMC7028019)

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Scaling is a major obstacle to commercial application of membrane distillation (MD) for desalination. Contemporary understanding of scaling formation onto hydrophobic membrane was built on thermodynamic assumption of a non-slip condition. This research provides an alternative theory and a novel insight from a hydrodynamic view of slip boundary. We purposely selected three polyvinylidene difluoride (PVDF) membranes with different surface characteristics - namely a tailor made superhydrophobic micro-pillared (CF4-MP-PVDF), a micro-pillared (MP-PVDF) and a commercial (C-PVDF) membranes, for direct contact membrane distillation (DCMD) using a supersaturated CaSO4 feed. MD flux analysis showed that CF4-MP-PVDF was highly scaling resistant whereas the other two membranes were not. Nucleation energy barrier, wetting state factor and slip length were used to explain for the observed difference in scaling behavior. Results showed that hydrodynamic properties, such as the wetting state and slip length, play a critical role in determining the anti-scaling behavior of a hydrophobic membrane rather than the contact angle nor the thermodynamic nucleation energy barrier. New findings from this study serve as a new guideline for the fabrication of antiscaling membranes by creating a slippery surface.

Item Type:Articles
Additional Information:his work was funded by the European Union FP7 Project [FP7-242209-BIOSTAT-CHF; EudraCT 2010-020808-29] and supported by the John and Lucille van Geest Foundation, the British Heart Foundation (FS/15/10/31223) and the National Institute for Health Research Leicester Biomedical Research Centre.
Glasgow Author(s) Enlighten ID:Cleland, Professor John
Authors: Cao, T. H., Jones, D. J.L., Voors, A. A., Quinn, P. A., Sandhu, J. K., Chan, D. C.S., Parry, H. M., Mohan, M., Mordi, I. R., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zannad, F., Lang, C. C., and Ng, L. L.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:European Journal of Heart Failure
ISSN (Online):1879-0844
Published Online:06 November 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in European Journal of Heart Failure 22(1): 70-80
Publisher Policy:Reproduced under a Creative Commons license

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