Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer

MacDonald, A.J., Miller, J., Ramage, M.I., Greig, C., Stephens, N.A., Jacobi, C., Preston, T. , Fearon, K.C.H. and Skipworth, R.J.E. (2019) Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer. Clinical Nutrition, 38(6), pp. 2875-2880. (doi: 10.1016/j.clnu.2018.12.023) (PMID:30612853) (PMCID:PMC6876543)

Abstract

Introduction: Following the consensus definition of cancer cachexia, more studies are using CT scan analysis of truncal muscles as a marker of muscle wasting. However, how CT-derived body composition relates to function, strength and power in patients with cancer is largely unknown. Aims: We aimed to describe the relationship between CT truncal (L3) skeletal muscle index (SMI) and MRI quadriceps cross sectional area with lower limb strength, power and measures of complex function. Methods: Patients undergoing assessment for potentially curative surgery for oesophagogastric or pancreatic cancer were recruited from the regional upper gastrointestinal (UGI) or hepatopancreaticobiliary (HPB) multi-disciplinary team meetings. Maximum Isometric Knee Extensor Strength (IKES) and Maximum Leg Extensor Power (Nottingham Power Rig) (LEP) were used as measures of lower limb performance. Both Sit to Stand (STS) and Timed Up and Go (TUG) were used as measures of global complex muscle function. Muscle SMI was measured from routine CT scans at the level of the third lumbar vertebrae (L3) and MRI scan was used for the assessment of quadriceps muscles. Linear regression analysis was performed for CT SMI or MRI quadriceps as a predictor of each measure of performance. Results: Forty-four patients underwent assessment. Height and weight were significantly related to function in terms of quadriceps power, while only weight was associated with strength (P < 0.001). CT SMI was not related to measures of quadriceps strength or power but had significant association with more complex functional measures (P = 0.006, R2 = 0.234 and 0.0019, R2 = 0.175 for STS and TUG respectively). In comparison, both gross and fat-subtracted measures of quadriceps muscle mass from MRI were significantly correlated with quadriceps strength and power (P < 0.001), but did not show any significant association with complex functional measures. Conclusion: CT SMI and MRI quadriceps have been shown to reflect different aspects of functional ability with CT SMI being a marker of global muscle function and MRI quadriceps being specific to quadriceps power and strength. This should therefore be considered when choosing outcome measures for trials or definitions of muscle mass and function.

• Item Type: Articles
• Additional Information: This study was supported by Cancer Research UK (grant no. C1128/A7309).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Preston, Professor Tom
• Authors: MacDonald, A.J., Miller, J., Ramage, M.I., Greig, C., Stephens, N.A., Jacobi, C., Preston, T., Fearon, K.C.H., and Skipworth, R.J.E.
• College/School: College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: Clinical Nutrition
• Publisher: Elsevier
• ISSN: 0261-5614
• ISSN (Online): 1532-1983
• Published Online: 24 December 2018
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Clinical Nutrition 38(6):2875-2880
• Publisher Policy: Reproduced under a Creative Commons License