Heterogeneity in the recognition of Ostertagia circumcincta antigens by serum antibody from mature, infected sheep

McCririe, L., Bairden, K., Britton, C. , Buitkamp, J., McKeand, J.B. and Stear, M.J. (1997) Heterogeneity in the recognition of Ostertagia circumcincta antigens by serum antibody from mature, infected sheep. Parasite Immunology, 19(5), pp. 235-242. (doi:10.1046/j.1365-3024.1997.d01-202.x) (PMID:9194101)

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Abstract

The recognition of parasite molecules from third‐stage and adult Ostertagia circumcincta by serum antibody was studied in a group of matched, mature Scottish Blackface sheep that had been naturally and then deliberately infected. A total of 20 molecules was recognized in somatic extracts from third‐stage larvae and 31 molecules in somatic extracts from adult parasites. However, no sheep recognized all immunogenic molecules and no molecule was recognized by all sheep. There was no obvious relationship between recognition of any parasite antigen and polymorphism at class I loci or at the DRB1 class II locus of the major histocompatibility complex in these outbred animals. Only 15 molecules from third‐stage larvae were present at a frequency suitable for statistical analysis and recognition of three of these 15 molecules was associated with differences in worm burdens. Recognition of two of five molecules from adult parasites was associated with differences in worm length. These results indicate that variation in the recognition of specific, identifiable parasite molecules may be partly responsible for variation among sheep in resistance to O. circumcincta

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Britton, Dr Collette and Stear, Professor Mike
Authors: McCririe, L., Bairden, K., Britton, C., Buitkamp, J., McKeand, J.B., and Stear, M.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Parasite Immunology
Publisher:Wiley
ISSN:0141-9838
ISSN (Online):1365-3024

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