Total syntheses of 11-acetoxy-4-deoxyasbestinin D, 4-deoxyasbestinin C, asbestinin-10, -20, -21 and -23

Campbell, A., Mat Som, I., Wilson, C. and Clark, J. S. (2020) Total syntheses of 11-acetoxy-4-deoxyasbestinin D, 4-deoxyasbestinin C, asbestinin-10, -20, -21 and -23. Chemistry: A European Journal, 26(5), pp. 1155-1160. (doi: 10.1002/chem.201904998) (PMID:31710141)

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Abstract

Six members of the asbestinin family of marine diterpene natural products have been synthesized in an efficient and stereoselective manner from a single oxa‐bridged intermediate. Five of these natural products have not been synthesized previously and the structures of four of them have been confirmed as those proposed originally or following revisions to the original structures. The fifth natural product—asbestinin‐21—has been shown to be a diastereomer of the compound that had been proposed previously.

Item Type:Articles
Additional Information:Funding Information: Engineering and Physical Sciences Research Council. Grant Number: EP/L50497X, EP/K03058, EP/M506539/1, EP/M508056/1.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Campbell, Angus and Clark, Professor Stephen and Mat Som, Ian and Wilson, Dr Claire
Authors: Campbell, A., Mat Som, I., Wilson, C., and Clark, J. S.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemistry: A European Journal
Publisher:Wiley
ISSN:0947-6539
ISSN (Online):1521-3765
Published Online:11 November 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Chemistry: A European Journal 26:1155-1160
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190627Doctoral Training Grant 2013 - 2017Mary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/L50497X/1Research and Innovation Services
190490Engineering and Physical Sciences Doctoral Training Grant 2012-16Mary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/K503058/1Research and Innovation Services
190790EPSRC DTG 2014Mary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/M506539/1Research and Innovation Services
190906EPSRC 2015 DTPMary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/M508056/1Research and Innovation Services