Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities

Steele, C. W., Jamieson, N. B. and Carter, C. R. (2014) Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities. In: Wondrak, G. T. (ed.) Stress Response Pathways in Cancer. Springer, pp. 375-395. ISBN 9789401794206 (doi: 10.1007/978-94-017-9421-3_17)

Abstract

The association between inflammation and cancer has been established for well over 100 years. Only now are we beginning to unravel the complexities of the inflammatory mechanisms that are integral to the initiation and progression of cancer. From large observational studies, to in-depth mechanistic in vivo modelling studies every aspect of inflammatory dysregulation is being examined. Better understanding of the cellular and molecular processes mediating cancer associated inflammation and the vital role it plays in cancer progression have begun to be exploited for therapeutic benefit. Here we describe the rationale for study of inflammation in cancer, provide an overview of our current understanding of inflammatory dysregulation in cancer, and assess the possible therapeutic avenues to be explored. We use pancreatic cancer, one of the most biologically diverse and aggressive examples to inform our discussion.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Jamieson, Professor Nigel
• Authors: Steele, C. W., Jamieson, N. B., and Carter, C. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Publisher: Springer
• ISBN: 9789401794206