Flow-induced mechanotransduction in skeletal cells

Alfieri, R., Vassalli, M. and Viti, F. (2019) Flow-induced mechanotransduction in skeletal cells. Biophysical Reviews, 11(5), pp. 729-743. (doi: 10.1007/s12551-019-00596-1) (PMID:31529361)

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Human body is subject to many and variegated mechanical stimuli, actuated in different ranges of force, frequency, and duration. The process through which cells “feel” forces and convert them into biochemical cascades is called mechanotransduction. In this review, the effects of fluid shear stress on bone cells will be presented. After an introduction to present the major players in bone system, we describe the mechanoreceptors in bone tissue that can feel and process fluid flow. In the second part of the review, we present an overview of the biological processes and biochemical cascades initiated by fluid shear stress in bone cells.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vassalli, Dr Massimo
Authors: Alfieri, R., Vassalli, M., and Viti, F.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Biophysical Reviews
ISSN (Online):1867-2469
Published Online:16 September 2019
Copyright Holders:Copyright © International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2019
First Published:First published in Biophysical Reviews 11(5):729-743
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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