Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor

Dobson, A. J. , Johnston, P. R., Vilcinskas, A. and Rolff, J. (2012) Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor. Journal of Insect Physiology, 58(12), pp. 1556-1561. (doi: 10.1016/j.jinsphys.2012.09.009) (PMID:23041376)

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Understanding the evolutionary ecology of immune responses to persistent infection could provide fundamental insight into temporal dynamics or interactive mechanisms that could be co-opted for antibiotic treatment regimes. Additionally, identification of novel molecules involved in these processes could provide novel compounds for biotechnological development. The beetle Tenebrio molitor displays a high level of induced antimicrobial activity coincident with persistent immuno-resistant Staphylococcus aureus, and is the first invertebrate model for persistent infection. Here we present expressed sequence tags (ESTs) detected by suppression-subtraction hybridization of Tenebrio larvae after infection with S. aureus. Amongst others, we identified mRNAs coding for various oxidative enzymes and two antimicrobial peptides. These ESTs provide a foundation for mechanistic study of Tenebrio's immune system.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dobson, Dr Adam
Authors: Dobson, A. J., Johnston, P. R., Vilcinskas, A., and Rolff, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Journal of Insect Physiology
ISSN (Online):1879-1611
Published Online:04 October 2012

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