Comparing selection on S. aureus between antimicrobial peptides and common antibiotics

Dobson, A. J. , Purves, J., Kamysz, W. and Rolff, J. (2013) Comparing selection on S. aureus between antimicrobial peptides and common antibiotics. PLoS ONE, 8(10), e76521. (doi: 10.1371/journal.pone.0076521) (PMID:24204634) (PMCID:PMC3799789)

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With a diminishing number of effective antibiotics, there has been interest in developing antimicrobial peptides (AMPs) as drugs. However, any new drug faces potential bacterial resistance evolution. Here, we experimentally compare resistance evolution in Staphylococcus aureus selected by three AMPs (from mammals, amphibians and insects), a combination of two AMPs, and two antibiotics: the powerful last-resort vancomycin and the classic streptomycin. We find that resistance evolves readily against single AMPs and against streptomycin, with no detectable fitness cost. However the response to selection from our combination of AMPs led to extinction, in a fashion qualitatively similar to vancomycin. This is consistent with the hypothesis that simultaneous release of multiple AMPs during immune responses is a factor which constrains evolution of AMP resistant pathogens.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dobson, Dr Adam
Authors: Dobson, A. J., Purves, J., Kamysz, W., and Rolff, J.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2013 Dobson et al.
First Published:First published in PLoS ONE 8(10): e76521
Publisher Policy:Reproduced under a Creative Commons License

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