Zoonotic causes of febrile illness in malaria endemic countries: a systematic review

Halliday, J. E.B. et al. (2020) Zoonotic causes of febrile illness in malaria endemic countries: a systematic review. Lancet Infectious Diseases, 20(2), e27-e37. (doi: 10.1016/S1473-3099(19)30629-2) (PMID:32006517) (PMCID:PMC7212085)

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Abstract

Fever is one of the most common reasons for seeking health care globally and most human pathogens are zoonotic. We conducted a systematic review to describe the occurrence and distribution of zoonotic causes of human febrile illness reported in malaria endemic countries. We included data from 53 (48·2%) of 110 malaria endemic countries and 244 articles that described diagnosis of 30 zoonoses in febrile people. The majority (17) of zoonoses were bacterial, with nine viruses, three protozoa, and one helminth also identified. Leptospira species and non-typhoidal salmonella serovars were the most frequently reported pathogens. Despite evidence of profound data gaps, this Review reveals widespread distribution of multiple zoonoses that cause febrile illness. Greater understanding of the epidemiology of zoonoses in different settings is needed to improve awareness about these pathogens and the management of febrile illness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Halliday, Dr Jo and Ladbury, Georgia Ann Frances and Allan, Dr Kathryn and Cleaveland, Professor Sarah
Authors: Halliday, J. E.B., Carugati, M., Snavely, M. E., Allan, K. J., Beamesderger, J., Ladbury, G. A.F., Hoyle, D. V., Holland, P., Crump, J. A., Cleaveland, S., and Rubach, M. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Lancet Infectious Diseases
Publisher:Lancet Publishing Group
ISSN:1473-3099
ISSN (Online):1474-4457
Published Online:29 January 2020
Copyright Holders:Copyright © 2020 Elsevier Ltd.
First Published:First published in Lancet Infectious Diseases 20(2): e27-e37
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190437Impact, ecology and social determinants of bacterial zoonoses in northern TanzaniaSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/J010367/1Institute of Biodiversity, Animal Health and Comparative Medicine
190785Molecular epidemology of brucellosis in northern TanzaniaDaniel HaydonBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018845/1Institute of Biodiversity, Animal Health and Comparative Medicine
190825Social, economic and environmental drivers of zoonoses in Tanzania (SEEDZ)Sarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018926/1Institute of Biodiversity, Animal Health and Comparative Medicine
190535MRC Doctoral Training Grant 2012-16Margaret MacLeanMedical Research Council (MRC)MR/K500847/1 DTGInstitute of Cardiovascular & Medical Sciences
170521A One-Health approach to dissecting the diverse zoonotic causes of non-malaria febrile illnessDaniel HaydonThe Royal Society (ROYSOC)AA130131Institute of Biodiversity, Animal Health and Comparative Medicine
165842Leptospirosis in Tanzania; a study of the role of rodents in an emerging public health problem.Sarah CleavelandWellcome Trust (WELLCOTR)096400/Z/11/ZInstitute of Biodiversity, Animal Health and Comparative Medicine