Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy

Mescola, A., Vella, S., Scotto, M., Gavazzo, P., Canale, C., Diaspro, A., Pagano, A. and Vassalli, M. (2012) Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy. Journal of Molecular Recognition, 25(5), pp. 270-277. (doi: 10.1002/jmr.2173) (PMID:22528188)

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Abstract

Single‐cell force spectroscopy is an emerging technique in the field of biomedicine because it has proved to be a unique tool to obtain mechanical and functional information on living cells, with force resolution up to single molecular bonds. This technique was applied to the study of the cytoskeleton organisation of neuroblastoma cells, a life‐threatening cancer typically developing during childhood, and the results were interpreted on the basis of reference experiments on human embryonic kidney cell line. An intimate connection emerges among cellular state, cytoskeleton organisation and experimental outcome that can be potentially exploited towards a new method for cancer stadiation of neuroblastoma cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vassalli, Dr Massimo
Authors: Mescola, A., Vella, S., Scotto, M., Gavazzo, P., Canale, C., Diaspro, A., Pagano, A., and Vassalli, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Molecular Recognition
Publisher:Wiley
ISSN:1099-1352
ISSN (Online):1099-1352

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