Soloperto, A., Palazzolo, G., Tsushima, H., Chieregatti, E., Vassalli, M. and Difato, F. (2016) Laser nano-neurosurgery from gentle manipulation to nano-incision of neuronal cells and scaffolds: an advanced neurotechnology tool. Frontiers in Neuroscience, 10, 101. (doi: 10.3389/fnins.2016.00101) (PMID:27013962) (PMCID:PMC4786546)
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Abstract
Current optical approaches are progressing far beyond the scope of monitoring the structure and function of living matter, and they are becoming widely recognized as extremely precise, minimally-invasive, contact-free handling tools. Laser manipulation of living tissues, single cells, or even single-molecules is becoming a well-established methodology, thus founding the onset of new experimental paradigms and research fields. Indeed, a tightly focused pulsed laser source permits complex tasks such as developing engineered bioscaffolds, applying calibrated forces, transfecting, stimulating, or even ablating single cells with subcellular precision, and operating intracellular surgical protocols at the level of single organelles. In the present review, we report the state of the art of laser manipulation in neuroscience, to inspire future applications of light-assisted tools in nano-neurosurgery.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vassalli, Professor Massimo |
| Authors: | Soloperto, A., Palazzolo, G., Tsushima, H., Chieregatti, E., Vassalli, M., and Difato, F. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Frontiers in Neuroscience |
| Publisher: | Frontiers Media |
| ISSN: | 1662-453X |
| ISSN (Online): | 1662-453X |
| Copyright Holders: | Copyright © 2016 Soloperto, Palazzolo, Tsushima, Chieregatti, Vassalli and Difato |
| First Published: | First published in Frontiers in Neuroscience 10:101 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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