Consensus recommendations for resistance testing in the management of chronic hepatitis C virus infection: Public Health England HCV Resistance Group

Bradshaw, D. et al. (2019) Consensus recommendations for resistance testing in the management of chronic hepatitis C virus infection: Public Health England HCV Resistance Group. Journal of Infection, 79(6), pp. 503-512. (doi: 10.1016/j.jinf.2019.10.007) (PMID:31629015)

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Abstract

The treatment of hepatitis C virus (HCV) infection has been revolutionised by the advent of oral, well-tolerated, direct acting antiviral therapies (DAA), with high cure rates. However, in some scenarios, HCV resistance to antiviral therapies may have an impact on treatment success. Public Health England's HCV Resistance Group was established to support clinicians treating people with HCV, where the issue of resistance may be a factor in clinical decision-making, and this review includes the Group's current recommendations on the use of HCV resistance testing. The authors describe the principles behind and approach to HCV resistance testing and consider evidence from in vitro studies, clinical trials and real world cohorts on the impact of HCV resistance on treatment outcomes for particular DAA regimens. Five scenarios are identified in the UK and similar settings, where, in the Group's opinion, resistance testing should be performed.

Item Type:Articles
Keywords:Direct acting antivirals, Hepatitis C virus, resistance testing, sequencing.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Professor Emma and McLauchlan, Professor John
Authors: Bradshaw, D., Mbisa, J. L., Geretti, A. M., Healy, B. J., Cooke, G. S., Foster, G. R., Thomson, E. C., McLauchlan, J., Agarwal, K., Sabin, C., Mutimer, D., Moss, P., Irving, W. L., and Barnes, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Infection
Publisher:Elsevier
ISSN:0163-4453
ISSN (Online):1532-2742
Published Online:16 October 2019
Copyright Holders:Copyright © 2019 Crown Copyright
First Published:First published in Journal of Infection 79(6):503-512
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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