Give it or take it: the flux of one-carbon in cancer cells

Meiser, J. and Vazquez, A. (2016) Give it or take it: the flux of one-carbon in cancer cells. FEBS Journal, 283(20), pp. 3695-3704. (doi: 10.1111/febs.13731) (PMID:27042806)

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The sequence of the human genome together with sequence similarity analyses has advanced the discovery of missing steps in the mitochondrial one‐carbon metabolism pathway. That together with the revived interest in cancer metabolism has brought the research on one‐carbon metabolism back under the spotlight. Here, we present a brief review of recent advances in the field of one‐carbon metabolism, with a bias towards its relevance to cell growth and proliferation in human cancers. We will address the requirements of one‐carbon metabolism for biosynthesis and the major sources to satisfy that demand. We will also discuss some recent discoveries indicating a role of one‐carbon metabolism beyond biosynthesis. We conclude with a concise enumeration of some fundamental questions that remain unanswered.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vazquez, Alexei
Authors: Meiser, J., and Vazquez, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:FEBS Journal
ISSN (Online):1742-4658
Published Online:04 April 2016
Copyright Holders:Copyright © 2016 The Authors.
First Published:First published in FEBS Journal 283(20):3695-3704
Publisher Policy:Reproduced under a Creative Commons license

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