Immune responses in neurodegenerative diseases

Shrestha, R., Shakya Shrestha, S., Millington, O., Brewer, J. and Bushell, T. (2014) Immune responses in neurodegenerative diseases. Kathmandu University Medical Journal, 12(45), pp. 67-76.

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Publisher's URL: http://www.kumj.com.np/issue/45/67-76.pdf

Abstract

Neurodegenerative disease is a progressive loss of neurons from central nervous system and has a huge impact on health care system. Various causes have been proposed of which inflammation has been suggested to be a probable key factor in the most of such conditions. The involvement of immune cells including lymphocytes in such diseased condition of the CNS supports this notion. The effective therapy for these diseases has been sought for more than a half century but still lacking such therapy. On such basis this review article has mainly focussed on evidence of the involvement of immune cells in various neurodegenerative diseases including Alzheimer’s disease, Parkinson’s diseases and Multiple sclerosis and suggests a possible therapy of such diseased conditions of the CNS by the modulation of immune system.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brewer, Professor James
Authors: Shrestha, R., Shakya Shrestha, S., Millington, O., Brewer, J., and Bushell, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Kathmandu University Medical Journal
Publisher:Kathmandu University
ISSN:1812-2027
ISSN (Online):1812-2078

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