The Genetic Links to anxiety and depression (GLAD) study: online recruitment into the largest recontactable study of depression and anxiety

Davies, M. R. et al. (2019) The Genetic Links to anxiety and depression (GLAD) study: online recruitment into the largest recontactable study of depression and anxiety. Behaviour Research and Therapy, 123, 103503. (doi: 10.1016/j.brat.2019.103503) (PMID:31715324) (PMCID:PMC6891252)

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Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study ( recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

Item Type:Articles
Additional Information:This work was supported by the National Institute of Health Research (NIHR) BioResource, NIHR Biomedical Research Centre [IS-BRC-1215-20018], HSC R&D Division, Public Health Agency [COM/5516/18], MRC Mental Health Data Pathfinder Award (MC_PC_17,217), and the National Centre for Mental Health funding through Health and Care Research Wales.
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel and Lyall, Dr Donald
Authors: Davies, M. R., Kalsi, G., Armour, C., Jones, I. R., McIntosh, A. M., Smith, D. J., Walters, J. T.R., Bradley, J. R., Kingston, N., Ashford, S., Beange, I., Brailean, A., Cleare, A. J., Coleman, J. R.I., Curtis, C. J., Curzons, S. C.B., Davis, K. A.S., Dowey, L. R. C., Gault, V. A., Goldsmith, K. A., Bennett, M. H., Hirose, Y., Hotopf, M., Hübel, C., Kanz, C., Leng, J., Lyall, D. M., Mason, B. D., McAtarsney-Kovacs, M., Monssen, D., Moulton, A., Ovington, N., Palaiologou, E., Pariante, C. M., Parikh, S., Peel, A. J., Price, R. K., Rimes, K. A., Rogers, H. C., Sambrook, J., Skelton, M., Spaul, A., Suarez, E. L.A., Sykes, B. L., Thomas, K. G., Young, A. H., Vassos, E., Veale, D., White, K. M., Wingrove, J., Eley, T. C., and Breen, G.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Behaviour Research and Therapy
ISSN (Online):1873-622X
Published Online:24 October 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Behaviour Research and Therapy 123: 103503
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302957Mental Health Data PathfinderDaniel SmithMedical Research Council (MRC)MC_PC_17217HW - Mental Health and Wellbeing