Tibbo, A. J., Tejeda, G. S. and Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47(5), pp. 1557-1565. (doi: 10.1042/BST20190763) (PMID:31642904) (PMCID:PMC6824677)
|
Text
201906.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
Phosphodiesterases (PDEs) have long been considered as targets for the treatment of Alzheimer's disease (AD) and a substantial body of evidence suggests that one sub-family from the super-family of PDEs, namely PDE4D, has particular significance in this context. This review discusses the role of PDE4 in the orchestration of cAMP response element binding signaling in AD and outlines the benefits of targeting PDE4D specifically. We examine the limited available literature that suggests PDE4 expression does not change in AD brains together with reports that show PDE4 inhibition as an effective treatment in this age-related neurodegenerative disease. Actually, aging induces changes in PDE4 expression/activity in an isoform and brain-region specific manner that proposes a similar complexity in AD brains. Therefore, a more detailed account of AD-related alterations in cellular/tissue location and the activation status of PDE4 is required before novel therapies can be developed to target cAMP signaling in this disease.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tibbo, Dr Amy and Tejeda, Dr Gonzalo and Baillie, Professor George |
| Authors: | Tibbo, A. J., Tejeda, G. S., and Baillie, G. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Published Online: | 23 October 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Biochemical Society Transactions 47(5): 1557-1565 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric