Depressive symptoms, neuroticism and participation in breast and cervical cancer screening: cross-sectional and prospective evidence from UK Biobank

Niedzwiedz, C. L. , Robb, K. A. , Katikireddi, S. V. , Pell, J. P. and Smith, D. J. (2019) Depressive symptoms, neuroticism and participation in breast and cervical cancer screening: cross-sectional and prospective evidence from UK Biobank. Psycho-Oncology, (doi:10.1002/pon.5272) (PMID:31663185) (Early Online Publication)

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Abstract

Objective: To assess the cross‐sectional and prospective associations between depressive symptoms, neuroticism, and participation in breast and cervical screening in the UK. Methods: Women in the UK Biobank cohort with complete data who were eligible for breast cancer screening (aged 50‐70 years, N = 143 461) and/or cervical screening (<65 years, N = 141 753) at baseline recruitment (2006‐2010) and those with follow‐up data (2014‐2019) were identified (N = 11 050 and N = 9780 for breast and cervical screening). Depressive symptoms and neuroticism were self‐reported at baseline (range 0‐12 with higher scores reflecting greater severity). Primary outcomes were reporting being up to date with breast and cervical screening. For prospective analyses, patterns of screening participation from baseline to follow‐up were identified. Logistic regression was used to analyse associations, adjusted for potential confounding factors. Results: More severe depressive symptoms were associated with reduced likelihood of breast (OR = 0.960, 95% CI: 0.950,0.970) and cervical (OR = 0.958, 95% CI: 0.950,0.966) screening participation, in cross‐sectional analyses. Higher neuroticism scores were associated with reduced cervical screening participation, but the opposite was found for breast cancer screening. Examination of individual neuroticism items revealed that anxiety and worry were associated with increased breast screening. At follow‐up, higher baseline depressive symptoms were related to decreased cervical screening (OR = 0.955, 95% CI: 0.913,0.999), but not with breast screening. Conclusions: More severe depressive symptoms may be a barrier for breast and cervical screening and could be an indicator for more proactive strategies to improve uptake.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Katikireddi, Dr Vittal and Pell, Professor Jill and Smith, Professor Daniel and Niedzwiedz, Dr Claire and Robb, Dr Katie
Authors: Niedzwiedz, C. L., Robb, K. A., Katikireddi, S. V., Pell, J. P., and Smith, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO SPHSU
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Psycho-Oncology
Publisher:Wiley
ISSN:1057-9249
ISSN (Online):1099-1611
Published Online:30 October 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Psycho-Oncology 2019
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302182A machine learning approach to understanding comorbidity between mental and physical health conditionsJill PellMedical Research Council (MRC)MR/R024774/1HW - Public Health
302957Mental Health Data PathfinderDaniel SmithMedical Research Council (MRC)MC_PC_17217HW - Mental Health and Wellbeing
172690Understanding the impacts of welfare policy on health: A novel data linkage studySrinivasa KatikireddiChief Scientist Office (CSO)SCAF/15/02HW - Public Health
727651SPHSU Core Renewal: Measuring and Analysing Socioeconomic Inequalities in Health Research ProgrammeAlastair LeylandMedical Research Council (MRC)MC_UU_12017/13IHW - MRC/CSO SPHU
SPHSU13
727671SPHSU Core Renewal: Informing Healthy Public Policy Research ProgrammePeter CraigMedical Research Council (MRC)MC_UU_12017/15IHW - MRC/CSO SPHU
SPHSU15