Pseudokinases: a tribble‐edged sword

Richmond, L. and Keeshan, K. (2020) Pseudokinases: a tribble‐edged sword. FEBS Journal, 287(19), pp. 4170-4182. (doi: 10.1111/febs.15096) (PMID:31621188)

Abstract

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis, prognosis, prediction and clinical strategy. In their role as signalling mediators and scaffolding proteins, TRIBs lead to changes in protein stability and activity which impact on diverse cellular processes such as proliferation, differentiation, cell cycle and cell death. We review the role of TRIB proteins as promising therapeutic targets, with an emphasis on their role in cancer and as biomarkers with potential application across diverse pathological processes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Richmond, Dr Laura and Keeshan, Dr Karen
• Authors: Richmond, L., and Keeshan, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: FEBS Journal
• Publisher: Wiley
• ISSN: 1742-464X
• ISSN (Online): 1742-4658
• Published Online: 16 October 2019
• Copyright Holders: Copyright © 2019 Federation of European Biochemical Societies
• First Published: First published in FEBS Journal 287(19):4170-4182
• Publisher Policy: Reproduced in accordance with the publisher copyright policy