Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: a systematic review and meta‐analysis

Nikolaidou, T., Samuel, N. A., Marincowitz, C., Fox, D. J., Cleland, J. G.F. and Clark, A. L. (2020) Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: a systematic review and meta‐analysis. Annals of Noninvasive Electrocardiology, 25(1), e12710. (doi: 10.1111/anec.12710) (PMID:31603593) (PMCID:PMC7358891)

[img]
Preview
Text
201234.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

738kB

Abstract

Background: Little is known about ECG abnormalities in patients with heart failure and normal ejection fraction (HeFNEF) and how they relate to different etiologies or outcomes. Methods and Results: We searched the literature for peer‐reviewed studies describing ECG abnormalities in HeFNEF other than heart rhythm alone. Thirty five studies were identified and 32,006 participants. ECG abnormalities reported in patients with HeFNEF include atrial fibrillation (prevalence 12%–46%), long PR interval (11%–20%), left ventricular hypertrophy (LVH, 10%–30%), pathological Q waves (11%–18%), RBBB (6%–16%), LBBB (0%–8%), and long JTc (3%–4%). Atrial fibrillation is more common in patients with HeFNEF compared to those with heart failure and reduced ejection fraction (HeFREF). In contrast, long PR interval, LVH, Q waves, LBBB, and long JTc are more common in patients with HeFREF. A pooled effect estimate analysis showed that QRS duration ≥120 ms, although uncommon (13%–19%), is associated with worse outcomes in patients with HeFNEF. Conclusions: There is high variability in the prevalence of ECG abnormalities in patients with HeFNEF. Atrial fibrillation is more common in patients with HeFNEF compared to those with HeFREF. QRS duration ≥120 ms is associated with worse outcomes in patients with HeFNEF. Further studies are needed to address whether ECG abnormalities correlate with different phenotypes in HeFNEF.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleland, Professor John
Authors: Nikolaidou, T., Samuel, N. A., Marincowitz, C., Fox, D. J., Cleland, J. G.F., and Clark, A. L.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Annals of Noninvasive Electrocardiology
Publisher:Wiley
ISSN:1082-720X
ISSN (Online):1542-474X
Published Online:11 October 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Annals of Noninvasive Electrocardiology 25(1): e12710
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record