Integrin trafficking and the control of cell migration

Caswell, P. and Norman, J. (2006) Integrin trafficking and the control of cell migration. Traffic, 7, pp. 14-21. (doi:10.1111/j.1600-0854.2005.00362.x)

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Abstract

In the late 1980s and early 1990s, the observation that certain integrin heterodimers are continually internalized from the Plasma membrane into endosomal compartments and subsequently recycled back to the cell surface indicated that the endocytic and recycling pathways have the Potential to exert minute-to-minute control over integrin function. This insight has prompted others to study the regulation of integrin trafficking aims in more detail. This review to summarize the findings Of studies revealing the molecular mechanisms controlling integrin traffic, particularly those providing indications as to how these processes contribute to cell Migration and tumour cell invasiveness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Norman, Professor James
Authors: Caswell, P., and Norman, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Traffic
ISSN:1447-2538

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