The in vivo function of the p53 target gene TIGAR

Cheung, E. C., Athineos, D., Ridgway, R., Blyth, K. , Strathdee, D., Sansom, O. and Vousden, K. H. (2012) The in vivo function of the p53 target gene TIGAR. BMC Proceedings, 6, P12. (doi: 10.1186/1753-6561-6-S3-P12) (PMCID:PMC3395062)

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Abstract

The p53 tumour suppressor inhibits tumour development via various mechanisms such as apoptosis, inhibition of proliferation or the activation of senescence. Recently, several studies have indicated a novel role of p53 in the regulation of energy metabolism. Previously we have discovered TIGAR, a p53 target gene that acts as a fructose-2,6-bisphosphatase. TIGAR therefore can redirect glucose from the glycolytic pathway to the pentose phosphate pathway (PPP), which promotes NADPH production to generate reduced glutathione for protecting against ROS, and also ribose 5 phosphate production for nucleotide synthesis. In order to understand the function of TIGAR in vivo, we generated TIGAR deficient mice. We have determined a critical role of TIGAR in rapidly proliferating tissue, either for repair after damage or during tumor development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blyth, Professor Karen and Cheung, Mr Eric and Ridgway, Dr Rachel and Strathdee, Dr Douglas and Athineos, Mr Dimitris and Vousden, Karen and Sansom, Professor Owen
Authors: Cheung, E. C., Athineos, D., Ridgway, R., Blyth, K., Strathdee, D., Sansom, O., and Vousden, K. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:BMC Proceedings
Publisher:BioMed Central
ISSN:1753-6561
ISSN (Online):1753-6561
Copyright Holders:Copyright © 2012 Cheung et al.
First Published:First published in BMC Proceedings 6: P12
Publisher Policy:Reproduced under a Creative Commons License

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