Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression

Hall, A. P., Irvine, J., Blyth, K. , Cameron, E. R. , Onions, D. E. and Campbell, M. E.M. (1998) Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. Journal of Pathology, 186(2), pp. 209-214. (doi: 10.1002/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I) (PMID:9924438)

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Abstract

In order to investigate the role that the human T‐lymphotropic virus type I (HTLV‐I) tax oncogene plays in apoptosis and transformation in vivo, four lines of HTLV‐I tax transgenic mice were generated under the regulatory control of the CD3‐ϵ promoter–enhancer sequence. These mice develop a variety of phenotypes including mesenchymal tumours, which develop at wound sites, and salivary and mammary adenomas. In situ DNA fragment labelling and immunocytochemical analysis of these tumours reveals that they display enhanced levels of apoptosis, which is associated with elevated levels of Myc, Fos, Jun, and p53 protein expression. Furthermore, double immunofluorescent staining shows that Tax expression and apoptosis co‐localize, indicating that Tax expression is closely associated with apoptosis in vivo.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blyth, Professor Karen and Cameron, Professor Ewan and Onions, Professor David
Authors: Hall, A. P., Irvine, J., Blyth, K., Cameron, E. R., Onions, D. E., and Campbell, M. E.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Pathology
Publisher:Wiley
ISSN:0022-3417
ISSN (Online):1096-9896
Published Online:19 April 1999

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