Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P. and Chalmers, A. J. (2019) An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncology, 8(4), CNS47. (doi: 10.2217/cns-2019-0017) (PMID:31818127) (PMCID:PMC6974914)
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Abstract
Aim: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. Results: The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. Discussion: In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McLoone, Mr Philip and Chalmers, Professor Anthony |
Authors: | Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P., and Chalmers, A. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | CNS Oncology |
Publisher: | Future Medicine |
ISSN: | 2045-0907 |
ISSN (Online): | 2045-0915 |
Published Online: | 10 December 2019 |
Copyright Holders: | Copyright © 2019 Ming Yao Chong |
First Published: | First published in CNS Oncology 8(4):CNS47 |
Publisher Policy: | Reproduced under a Creative Commons License |
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