Protein turnover and differentiation in Leishmania

Besteiro, S., Williams, R. A.M., Coombs, G. H. and Mottram, J. C. (2007) Protein turnover and differentiation in Leishmania. International Journal for Parasitology, 37, pp. 1063-1075. (doi:10.1016/j.ijpara.2007.03.008)

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Leishmania occurs in several developmental forms and thus undergoes complex cell differentiation events during its life-cycle. Those are required to allow the parasite to adapt to the different environmental conditions. The sequencing of the genome of L. major has facilitated the identification of the parasite’s vast arsenal of proteolytic enzymes, a few of which have already been carefully studied and found to be important for the development and virulence of the parasite. This review focuses on these peptidases and their role in the cellular differentiation of Leishmania through their key involvement in a variety of degradative pathways in the lysosomal and autophagy networks.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Mottram, Professor Jeremy and Coombs, Professor Graham
Authors: Besteiro, S., Williams, R. A.M., Coombs, G. H., and Mottram, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal for Parasitology
ISSN (Online):1879-0135
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
297261Post-genomic analysis of cysteine protease function in Leishmania parasitesJeremy MottramMedical Research Council (MRC)G0000508Infection Immunity and Inflammation Life Sciences