Thermoplastic elastomer hydrogels via self-assembly of an elastin-mimetic triblock polypeptide

Wright, E.R., McMillan, R.A., Cooper, A., Apkarian, R.P. and Conticello, V.P. (2002) Thermoplastic elastomer hydrogels via self-assembly of an elastin-mimetic triblock polypeptide. Advanced Functional Materials, 12(2), pp. 149-154. (doi:10.1002/1616-3028(20020201)12:2<149::AID-ADFM149>3.0.CO;2-N)

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Publisher's URL: http://dx.doi.org/10.1002/1616-3028(20020201)12:2<149::AID-ADFM149>3.0.CO;2-N

Abstract

Protein-based analogues of conventional thermoplastic elastomers can be designed with enhanced properties as a consequence of the precise control of primary structure. Protein 1 undergoes a reversible sol-gel transition, which results in the formation of a well-defined elastomeric network above a lower critical solution temperature. The morphology of the network is consistent with selective microscopic phase separation of the endblock domains. This genetic engineering approach provides a method for specification of the critical architectural parameters. such as block length and sequence, which define macromolecular properties that are important for downstream applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cooper, Professor Alan
Authors: Wright, E.R., McMillan, R.A., Cooper, A., Apkarian, R.P., and Conticello, V.P.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Advanced Functional Materials
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1616-301X
ISSN (Online):1616-3028

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