Virus evolution in Wolbachia-infected Drosophila

Martinez, J. , Bruner-Montero, G., Arunkumar, R., Smith, S. C.L., Day, J. P., Longdon, B. and Jiggins, F. M. (2019) Virus evolution in Wolbachia-infected Drosophila. Proceedings of the Royal Society of London Series B: Biological Sciences, 286, 20192117. (doi: 10.1098/rspb.2019.2117) (PMID:31662085) (PMCID:PMC6823055)

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Abstract

Wolbachia, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, Wolbachia-infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of Wolbachia. We have found that Wolbachia altered the outcome of competition between strains of the DCV virus in Drosophila. However, Wolbachia still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that Wolbachia did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.

Item Type:Articles
Additional Information:Funders: Wellcome Trust grant WT094664MA and the European Research Council (ERC) grant 281668 DrosophilaInfection.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Martinez, Dr Julien
Authors: Martinez, J., Bruner-Montero, G., Arunkumar, R., Smith, S. C.L., Day, J. P., Longdon, B., and Jiggins, F. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Proceedings of the Royal Society of London Series B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8452
ISSN (Online):1471-2954
Published Online:30 October 2019
Copyright Holders:Copyright © 2019 The Author(s)
First Published:First published in Proceedings of the Royal Society of London Series B: Biological Sciences 286:20192117
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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