Mesoporous chitosan based conformable and resorbable biostrip for Dopamine detection

Kafi, M. A., Paul, A., Vilouras, A. and Dahiya, R. (2020) Mesoporous chitosan based conformable and resorbable biostrip for Dopamine detection. Biosensors and Bioelectronics, 147, 111781. (doi: 10.1016/j.bios.2019.111781) (PMID:31629214)

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Abstract

This work presents a chitosan based resorbable biostrip for label-free electrochemical detection of dopamine (DA).The biostrip consists of mesoporous-chitosan-graphene oxide (m-Chit-GO) composite-based sensing electrode and graphene-based interconnects. Obtained with particulate leaching, the m-chit-GO showed average pore size of 1μmwith slow (2 h) curing process. The response of DA on m-Chit-GO was investigated and compared with their bulk counterpart to study the effect of mesoporosity on voltammogram output signals. The voltammetric investigations were performed with three-electrode set-up using m-Chit-GO electrode as working electrode whereas Ag/AgCl and Graphene were used as a reference and counter electrodes, respectively. The quantitative analysis of concentration-dependent voltammetric peak-current enhancement revealed significantly higher response for m-Chit-GO (10pM) as compared to their bulk state (100 nM) on DA. The presented resorbable biostrip offers a limit of detection of 10pM and thereby shows great promise for detection of DA levels for early diagnosis of neurodegenerative diseases.

Item Type:Articles
Additional Information:This work was supported in part by the European Commission through Marie Curie Fellowship (H2020-MSCA-IF-2015-704807), the Academy of Medical Sciences (NF161567) and EPSRC through Engineering Fellowship for Growth - (EP/M002527/1 and EP/R029644/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kafi, Md Abdul and Vilouras, Anastasios and Dahiya, Professor Ravinder and Paul, Dr Ambarish
Authors: Kafi, M. A., Paul, A., Vilouras, A., and Dahiya, R.
College/School:College of Science and Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Biosensors and Bioelectronics
Publisher:Elsevier
ISSN:0956-5663
ISSN (Online):0956-5663
Published Online:11 October 2019
Copyright Holders:Copyright © 2019 Elsevier B.V.
First Published:First published in Biosensors and Bioelectronics 147: 111781
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
170185Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/M002527/1ENG - Electronics & Nanoscale Engineering
172808BENDRavinder DahiyaEuropean Commission (EC)704807ENG - Electronics & Nanoscale Engineering